Liver-specific expression of ANGPTL8 promotes Alzheimer’s disease progression through activating microglial pyroptosis

Abstract Introduction Liver dysfunction contributes to Alzheimer’s disease (AD) pathogenesis, and evidence suggests that the liver is involved in amyloid β (Aβ) clearance, and regulates Aβ deposition in the brain. However, the specific regulatory mechanism remains elusive. Objectives Angiopoietin-li...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Journal of Neuroinflammation
المؤلفون الرئيسيون:	Jiarui Wei, Lin Hu, Shufan Xu, Fan Yang, Fusheng Liao, Ying Tang, Xin Shen, Xiaoqiao Zhang, Xinggang Fang, Yifan Li, Li Ding, Zhuo Chen, Shanchun Su, Junhua Cheng, Yong Huang, Qian Chen, Daqing Ma, Qiufang Zhang, Xingrong Guo
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	BMC 2025-07-01
الموضوعات:	ANGPTL8 Neuroinflammation Liver‒brain axis Microglial pyroptosis Alzheimer's disease
الوصول للمادة أونلاين:	https://doi.org/10.1186/s12974-025-03487-3