Single-Nucleus RNA-seq of Normal-Appearing Brain Regions in Relapsing-Remitting vs. Secondary Progressive Multiple Sclerosis: Implications for the Efficacy of Fingolimod

Multiple sclerosis (MS) is an immune-mediated demyelinating disease that alters central nervous system (CNS) functions. Relapsing-remitting MS (RRMS) is the most common form, which can transform into secondary-progressive MS (SPMS) that is associated with progressive neurodegeneration. Single-nucleu...

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Bibliographic Details

Published in:	Frontiers in Cellular Neuroscience
Main Authors:	Yasuyuki Kihara, Yunjiao Zhu, Deepa Jonnalagadda, William Romanow, Carter Palmer, Benjamin Siddoway, Richard Rivera, Ranjan Dutta, Bruce D. Trapp, Jerold Chun
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Subjects:	neuroinflammation S1P1 FTY720 siponimod ozanimod ponesimod
Online Access:	https://www.frontiersin.org/articles/10.3389/fncel.2022.918041/full