A multiverse of α-synuclein: investigation of prion strain properties with carboxyl-terminal truncation specific antibodies in animal models

Abstract Synucleinopathies are a group of neurodegenerative disorders characterized by the presence of misfolded α-Synuclein (αSyn) in the brain. These conditions manifest with diverse clinical and pathophysiological characteristics. This disease diversity is hypothesized to be driven by αSyn strain...

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الحاوية / القاعدة:	Acta Neuropathologica Communications
المؤلفون الرئيسيون:	Grace M. Lloyd, Stephan Quintin, Zachary A. Sorrentino, Kimberly-Marie M. Gorion, Brach M. Bell, Brooke Long, Giavanna Paterno, Benoit I. Giasson
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	BMC 2024-06-01
الموضوعات:	α-Synuclein C-terminal truncation Prion-type Strains Parkinson’s disease Multiple system atrophy
الوصول للمادة أونلاين:	https://doi.org/10.1186/s40478-024-01805-z