N6‐isopentenyladenosine inhibits aerobic glycolysis in glioblastoma cells by targeting PKM2 expression and activity

Glioblastoma (GBM) is a primary tumor in the central nervous system with poor prognosis. It exhibits elevated glucose uptake and lactate production. This metabolic state of aerobic glycolysis is known as the Warburg effect. N6‐isopentenyladenosine (iPA), a natural cytokine modified with an isopenten...

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Bibliographic Details

Published in:	FEBS Open Bio
Main Authors:	Cristina Pagano, Laura Coppola, Giovanna Navarra, Giorgio Avilia, Beatrice Savarese, Giovanni Torelli, Sara Bruzzaniti, Erica Piemonte, Mario Galgani, Chiara Laezza, Maurizio Bifulco
Format:	Article
Language:	English
Published:	Wiley 2024-05-01
Subjects:	cancer metabolism glioblastoma glycolysis iPA PKM2
Online Access:	https://doi.org/10.1002/2211-5463.13766