Novel Pyrrole Derivatives as Multi-Target Agents for the Treatment of Alzheimer’s Disease: Microwave-Assisted Synthesis, In Silico Studies and Biological Evaluation

Considering the complex pathogenesis of Alzheimer’s disease (AD), the multi-target ligand strategy is expected to provide superior effects for the treatment of the neurological disease compared to the classic single target strategy. Thus, one novel pyrrole-based hydrazide (<b>vh0</b>) an...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Emilio Mateev, Valentin Karatchobanov, Marjano Dedja, Konstantinos Diamantakos, Alexandrina Mateeva, Muhammed Tilahun Muhammed, Ali Irfan, Magdalena Kondeva-Burdina, Iva Valkova, Maya Georgieva, Alexander Zlatkov
Format:	Article
Language:	English
Published:	MDPI AG 2024-09-01
Subjects:	microwave-assisted synthesis pyrrole hydrazide–hydrazones antioxidants oxidative stress molecular docking
Online Access:	https://www.mdpi.com/1424-8247/17/9/1171