Defects of mitochondria-lysosomes communication induce secretion of mitochondria-derived vesicles and drive chemoresistance in ovarian cancer cells

Abstract Background Among the mechanisms of mitochondrial quality control (MQC), generation of mitochondria-derived vesicles (MDVs) is a process to avoid complete failure of mitochondria determining lysosomal degradation of mitochondrial damaged proteins. In this context, RAB7, a late endocytic smal...

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Bibliographic Details

Published in:	Cell Communication and Signaling
Main Authors:	Sinforosa Gagliardi, Marco Mitruccio, Riccardo Di Corato, Roberta Romano, Alessandra Aloisi, Rosaria Rinaldi, Pietro Alifano, Flora Guerra, Cecilia Bucci
Format:	Article
Language:	English
Published:	BMC 2024-03-01
Subjects:	RAB7 Mitochondria-derived vesicles Extracellular vesicles Cisplatin chemoresistance Ovarian cancer
Online Access:	https://doi.org/10.1186/s12964-024-01507-y