Amitriptyline revitalizes ICB response via dually inhibiting Kyn/Indole and 5-HT pathways of tryptophan metabolism in ovarian cancer

Summary: Reprogramming tryptophan metabolism (TRP) may be able to overcome immunosuppression and restore the immune checkpoint blockade (ICB) response in patients with epithelial ovarian cancer (EOC) resistant to ICB therapy because TRP metabolism is involved in the kynurenine/indole and serotonin p...

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Bibliographic Details

Published in:	iScience
Main Authors:	Junyang Li, Bingjie Mei, Lu Feng, Xiaoxin Wang, Dengfeng Wang, Jianming Huang, Guonan Zhang
Format:	Article
Language:	English
Published:	Elsevier 2024-12-01
Subjects:	Cancer Immune response Microenvironment
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004224027159