NADH elevation during chronic hypoxia leads to VHL-mediated HIF-1α degradation via SIRT1 inhibition

Abstract Background Under conditions of hypoxia, cancer cells with hypoxia inducible factor-1α (HIF-1α) from heterogeneous tumor cells show greater aggression and progression in an effort to compensate for harsh environmental conditions. Extensive study on the stability of HIF-1α under conditions of...

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Bibliographic Details

Published in:	Cell & Bioscience
Main Authors:	Hyun-Yoo Joo, Jin Kyu Jung, Mi-Yeon Kim, Seon Rang Woo, Jae Min Jeong, Eun-Ran Park, Yong-Min Kim, Joong-Jean Park, Joon Kim, Miyong Yun, Hyun-Jin Shin, Kee-Ho Lee
Format:	Article
Language:	English
Published:	BMC 2023-09-01
Subjects:	Chronic hypoxia NADH elevation HIF-1α degradation SIRT1 VHL Invasion
Online Access:	https://doi.org/10.1186/s13578-023-01130-3