Genetic polymorphism of cytochrome P450 4F2, vitamin E level and histological response in adults and children with nonalcoholic fatty liver disease who participated in PIVENS and TONIC clinical trials.

Vitamin E improved liver histology in children and adults with NAFLD who participated in TONIC and PIVENS clinical trials, but with significant inter-individual variability in its efficacy. Cytochrome P450 4F2 (CYP4F2) is the major enzyme metabolizing Vit E, with two common genetic variants (V433M,...

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Published in:	PLoS ONE
Main Authors:	Shaminie Athinarayanan, Rongrong Wei, Min Zhang, Shaochun Bai, Maret G Traber, Katherine Yates, Oscar W Cummings, Jean Molleston, Wanqing Liu, Naga Chalasani
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2014-01-01
Online Access:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0095366&type=printable