Oligomeric S100A4 Is Associated With Monocyte Innate Immune Memory and Bypass of Tolerance to Subsequent Stimulation With Lipopolysaccharides

Objectives: Most DAMPs in inflammatory diseases are TLR2- and TLR4-ligands and according to the current concept, repeated stimuli would result in tolerance. Aims of the study were to verify this assumption, to investigate whether epigenetic effectors are involved and to explore the situation in rheu...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Frontiers in Immunology
المؤلفون الرئيسيون:	Michel Neidhart, Agnieszka Pajak, Katerina Laskari, Niels P. Riksen, Leo A. B. Joosten, Mihai G. Netea, Esther Lutgens, Eric S. G. Stroes, Adrian Ciurea, Oliver Distler, Mariam Grigorian, Emmanuel Karouzakis
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Frontiers Media S.A. 2019-04-01
الموضوعات:	trained immunity DAMPs S100A4 protein epigenetic rheumatoid arthritis
الوصول للمادة أونلاين:	https://www.frontiersin.org/article/10.3389/fimmu.2019.00791/full