Emerging targets of α-synuclein spreading in α-synucleinopathies: a review of mechanistic pathways and interventions

Abstract α-Synucleinopathies constitute a spectrum of neurodegenerative disorders, including Parkinson’s disease (PD), Lewy body dementia (LBD), Multiple System Atrophy (MSA), and Alzheimer’s disease concurrent with LBD (AD-LBD). These disorders are unified by a pathological hallmark: aberrant misfo...

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Bibliographic Details

Published in:	Molecular Neurodegeneration
Main Authors:	Grace Kuo, Ramhari Kumbhar, William Blair, Valina L. Dawson, Ted M. Dawson, Xiaobo Mao
Format:	Article
Language:	English
Published:	BMC 2025-01-01
Subjects:	Prion-like α-synuclein Spreading Receptor Therapeutic targets
Online Access:	https://doi.org/10.1186/s13024-025-00797-1