CD8⁺ T Cells Mediate Lethal Lung Pathology in the Absence of PD-L1 and Type I Interferon Signalling following LCMV Infection

CD8⁺ T cells are critical to the adaptive immune response against viral pathogens. However, overwhelming antigen exposure can result in their exhaustion, characterised by reduced effector function, failure to clear virus, and the upregulation of inhibitory receptors, including...

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Bibliographic Details

Published in:	Viruses
Main Authors:	Alanna G. Spiteri, Tamara Suprunenko, Erin Cutts, Andrew Suen, Thomas M. Ashhurst, Barney Viengkhou, Nicholas J. C. King, Markus J. Hofer
Format:	Article
Language:	English
Published:	MDPI AG 2024-03-01
Subjects:	lymphocytic choriomeningitis virus (LCMV) T cell exhaustion lung pathology type 1 interferon IFNAR1 PD-L1
Online Access:	https://www.mdpi.com/1999-4915/16/3/390