GRA24-Based DNA Vaccine Prolongs Survival in Mice Challenged With a Virulent Toxoplasma gondii Strain

Toxoplasma gondii causes infections in a wide range of intermediate hosts and remains a threatening disease worldwide because of the lack of effective drugs and vaccines. Dense granule protein 24 (GRA24) is a novel essential virulence factor that is transferred into the nucleus of host cells from th...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Bin Zheng, Di Lou, Jianzu Ding, Xunhui Zhuo, Haojie Ding, Qingming Kong, Shaohong Lu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-03-01
Subjects:	Toxoplasma gondii immunization DNA vaccine GRA24 Th1/Th2 cytokines
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2019.00418/full