Reversing NK cell exhaustion: a novel strategy combining immune checkpoint blockade with drug sensitivity enhancement in the treatment of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the most common lethal cancers worldwide. Natural killer cells (NK cells) play a key role in liver immunosurveillance, but in the tumor microenvironment, NK cells are readily depleted, as evidenced by down-regulation of activating receptors, reduced cytokine...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Yuxiang Huang, Hengjian Liao, Jiefu Luo, Huaning Wei, Anling Li, Yujie Lu, Bangde Xiang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Subjects:	hepatocellular carcinoma NK cell exhaustion immunotherapy immune checkpoint blockade drug sensitivity tumor microenvironment
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1502270/full