Augmenting the Antitumor Efficacy of Natural Killer Cells via SynNotch Receptor Engineering for Targeted IL-12 Secretion

Natural killer (NK) cells are crucial components of innate immunity, known for their potent tumor surveillance abilities. Chimeric antigen receptors (CARs) have shown promise in cancer targeting, but optimizing CAR designs for NK cell functionality remains challenging. CAR-NK cells have gained atten...

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Bibliographic Details

Published in:	Current Issues in Molecular Biology
Main Authors:	Ali Ahmadnia, Saeed Mohammadi, Ahad Yamchi, Mohamad Reza Kalani, Touraj Farazmandfar, Ayyoub Khosravi, Ali Memarian
Format:	Article
Language:	English
Published:	MDPI AG 2024-03-01
Subjects:	NK cell synNotch receptor IL-12 IFNγ cytotoxicity breast cancer
Online Access:	https://www.mdpi.com/1467-3045/46/4/183