Cladribine treatment specifically affects peripheral blood memory B cell clones and clonal expansion in multiple sclerosis patients

IntroductionB cells are acknowledged as crucial players in the pathogenesis of multiple sclerosis (MS). Several disease modifying drugs including cladribine have been shown to exert differential effects on peripheral blood B cell subsets. However, little is known regarding functional changes within...

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الحاوية / القاعدة:	Frontiers in Immunology
المؤلفون الرئيسيون:	Christoph Ruschil, Gisela Gabernet, Constanze Louisa Kemmerer, Mohamed Ali Jarboui, Franziska Klose, Sven Poli, Ulf Ziemann, Sven Nahnsen, Markus Christian Kowarik
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Frontiers Media S.A. 2023-03-01
الموضوعات:	multiple sclerosis B cells cladribine immunoglobulin repertoire next generation sequencing immunoglobulin proteome analysis
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1133967/full