Genetic Ablation of the Mitochondrial Calcium Uniporter (MCU) Does not Impair T Cell-Mediated Immunity In Vivo

T cell activation and differentiation is associated with metabolic reprogramming to cope with the increased bioenergetic demand and to provide metabolic intermediates for the biosynthesis of building blocks. Antigen receptor stimulation not only promotes the metabolic switch of lymphocytes but also...

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الحاوية / القاعدة:	Frontiers in Pharmacology
المؤلفون الرئيسيون:	Hao Wu, Benjamin Brand, Miriam Eckstein, Sophia M. Hochrein, Magdalena Shumanska, Jan Dudek, Alexander Nickel, Christoph Maack, Ivan Bogeski, Martin Vaeth
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Frontiers Media S.A. 2021-12-01
الموضوعات:	mitochondrial calcium uniporter (MCU) store-operated Ca2+ entry mitochondria oxidative phosphorylation calcium (Ca2+) immunometabolism
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fphar.2021.734078/full