Engineering of CD8+ T cells with an HIV-specific synthetic notch receptor to secrete broadly therapeutic antibodies for combining antiviral humoral and cellular immune responses

ABSTRACT The application of immunotherapeutic strategies, such as chimeric antigen receptor-T cells and broadly neutralizing antibodies (bNAbs), for the treatment of human immunodeficiency virus (HIV) infection is hindered by the latent reservoirs and viral escape. Achieving long-term control of vir...

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Bibliographic Details

Published in:	mBio
Main Authors:	Lina Meng, Haichi Zhao, Shangkun Chang, Weiting Li, Yinghui Tian, Ruihong Wang, Libian Wang, Tiejun Gu, Jiaxin Wu, Bin Yu, Chu Wang, Xianghui Yu
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-04-01
Subjects:	HIV-1 synNotch broadly neutralizing antibody T cell re-targeting antibody CD8+ T cell cell engineering
Online Access:	https://journals.asm.org/doi/10.1128/mbio.03839-24