High Expression of the Costimulatory Checkpoint Factor DNAM-1 by CD4+ T-Cells from Multiple Myeloma Patients Refractory to Daratumumab-Containing Regimens

Abstract Multiple myeloma is an incurable disease characterized by unregulated growth of malignant plasma cells in the bone marrow (BM). Tumor-induced dysfunction of T-cells may be responsible for immune evasion and failure of immunotherapy. Therefore, a better understanding of the phenotype of T-ce...

Full description

Bibliographic Details

Published in:	Clinical Hematology International
Main Authors:	Katrine Fladeland Iversen, Line Nederby, Thomas Lund, Torben Plesner
Format:	Article
Language:	English
Published:	SAABRON PRESS 2022-08-01
Subjects:	Multiple myeloma Bone marrow microenvironment Treatment Immunotherapy Daratumumab Checkpoint inhibitor
Online Access:	https://doi.org/10.1007/s44228-022-00013-7