Different Mechanisms of Catalytic Complex Formation in Two L-Tryptophan Processing Dioxygenases

The human heme enzymes tryptophan 2,3-dioxygenase (hTDO) and indoleamine 2,3 dioxygenase (hIDO) catalyze the initial step in L-tryptophan (L-Trp) catabolism, the insertion of dioxygen into L-Trp. Overexpression of these enzymes causes depletion of L-Trp and accumulation of metabolic products, and th...

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Bibliographic Details

Published in:	Frontiers in Molecular Biosciences
Main Authors:	Karin Nienhaus, G. Ulrich Nienhaus
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-01-01
Subjects:	indoleamine 2 3-dioxygenase tryptophan dioxygenase flash photolysis self-inhibition ternary complex formation
Online Access:	http://journal.frontiersin.org/article/10.3389/fmolb.2017.00094/full