SPP1+ tumor-associated macrophages define a high-risk subgroup and inform personalized therapy in hepatocellular carcinoma

IntroductionRecently, contrary to attacking cancer cells, the tumor microenvironment (TME) with genomic stability and vulnerable nature has emerged as promising therapeutic targets in hepatocellular carcinoma (HCC). Within TME ecosystem, tumor-associated macrophages (TAMs) play a pivotal role in tum...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Wei-Xuan Xu, Ya-Mei Ye, Jia-Lin Chen, Xin-Ying Guo, Chen Li, Juan Luo, Lin-Bin Lu, Xiong Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Subjects:	hepatocellular carcinoma tumor-associated macrophages single-cell RNA-seq patient stratification clinical treatment
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1606195/full