Cryptotanshinone Ameliorates Doxorubicin-Induced Cardiotoxicity by Targeting Akt-GSK-3β-mPTP Pathway In Vitro

Cardiotoxicity is one of the main side effects of doxorubicin (Dox) treatment. Dox could induce oxidative stress, leading to an opening of the mitochondrial permeability transition pore (mPTP) and apoptosis in cardiomyocytes. Previous studies have shown that Cryptotanshinone (Cts) has potential card...

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发表在:	Molecules
Main Authors:	Xiaoping Wang, Qianbin Sun, Qianqian Jiang, Yanyan Jiang, Yawen Zhang, Jing Cao, Linghui Lu, Chun Li, Peng Wei, Qiyan Wang, Yong Wang
格式:	文件
语言:	英语
出版:	MDPI AG 2021-03-01
主题:	cardiotoxicity doxorubicin cryptotanshinone oxidative stress apoptosis mPTP
在线阅读:	https://www.mdpi.com/1420-3049/26/5/1460