Mitochondrial impairment and repair in the pathogenesis of systemic lupus erythematosus

Nucleic acid autoantibodies, increase type I interferon (IFN-α) levels, and immune cell hyperactivation are hallmarks of systemic lupus erythematosus (SLE). Notably, immune cell activation requires high level of cellular energy that is predominately generated by the mitochondria. Mitochondrial react...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Like Zhao, Xianda Hu, Fei Xiao, Xuan Zhang, Lidan Zhao, Min Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-07-01
Subjects:	systemic lupus erythematosus mitochondrial reactive oxygen species mitochondrial dysfunction mitophagy oxidative stress mitochondria targeting therapeutics
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.929520/full