Insights into regulatory T-cell and type-I interferon roles in determining abacavir-induced hypersensitivity or immune tolerance

IntroductionClinical use of several small molecule drugs may lead to severe T-cell-mediated idiosyncratic drug hypersensitivity reactions (iDHR) linked to HLA alleles, including abacavir (ABC) with HLA-B*57:01. Due to study limitations in humans, pathogenic networks in iDHR remain elusive. HLA trans...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Marco Cardone, Hratch M. Baghdassarian, Maryam Khalaj, Kirthiram Krishnaveni Sivakumar, SuJin Hwang, Sintayehu Gebreyohannes, Kazuyo Takeda, Yura Jang, Nathan E. Lewis, Michael A. Norcross, Montserrat Puig
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-06-01
Subjects:	drug hypersensitivity reactions abacavir Treg type-I IFN T-cell HLA
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1612451/full