Recombinant PrP and Its Contribution to Research on Transmissible Spongiform Encephalopathies

The misfolding of the cellular prion protein (PrPC) into the disease-associated isoform (PrPSc) and its accumulation as amyloid fibrils in the central nervous system is one of the central events in transmissible spongiform encephalopathies (TSEs). Due to the proteinaceous nature of the causal agent...

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Bibliographic Details

Published in:	Pathogens
Main Authors:	Jorge M. Charco, Hasier Eraña, Vanessa Venegas, Sandra García-Martínez, Rafael López-Moreno, Ezequiel González-Miranda, Miguel Ángel Pérez-Castro, Joaquín Castilla
Format:	Article
Language:	English
Published:	MDPI AG 2017-12-01
Subjects:	Prion disease TSE recombinant PrP in vitro propagation PMCA QuIC
Online Access:	https://www.mdpi.com/2076-0817/6/4/67