ITF6475, a New Histone Deacetylase 6 Inhibitor, Prevents Painful Neuropathy Induced by Paclitaxel

Chemotherapy-induced peripheral neuropathy remains a significant side effect of cancer treatment, often requiring dose reductions or even discontinuation of therapy. Paclitaxel (PTX), a widely used chemotherapeutic agent for solid tumors, is particularly neurotoxic, and no effective treatment exists...

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Bibliographic Details

Published in:	Toxics
Main Authors:	Guido Cavaletti, Annalisa Canta, Alessia Chiorazzi, Eleonora Pozzi, Valentina Carozzi, Cristina Meregalli, Paola Alberti, Paola Marmiroli, Arianna Scuteri, Luca Crippa, Silvia Fermi, Ibtihal Segmani, Barbara Vergani, Christian Steinkühler, Simonetta Andrea Licandro
Format:	Article
Language:	English
Published:	MDPI AG 2025-09-01
Subjects:	paclitaxel neuropathy histone deacetylase 6 neuroprotection small fibers ITF6475
Online Access:	https://www.mdpi.com/2305-6304/13/9/767