Synthesis and Biological Evaluation of New Bis-Indolinone Derivatives Endowed with Cytotoxic Activity

A series of new Knoevenagel adducts, bearing two indolinone systems, has been synthesized and evaluated on 60 human cancer cell lines according to protocols available at the National Cancer Institute (Bethesda, MD, USA). Some derivatives proved to be potent antiproliferative agents, showing GI<su...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Rita Morigi, Elena Catanzaro, Alessandra Locatelli, Cinzia Calcabrini, Valentina Pellicioni, Alberto Leoni, Carmela Fimognari
Format:	Article
Language:	English
Published:	MDPI AG 2021-10-01
Subjects:	programmed cell death cell cycle small molecules indolinone systems Knoevenagel reaction
Online Access:	https://www.mdpi.com/1420-3049/26/20/6277