Theoretical analysis of low power optogenetic control of synaptic plasticity with subcellular expression of CapChR2 at postsynaptic spine

Abstract Precise control of intracellular calcium ( $${Ca}^{2+}$$ ) concentration at the synaptic neuron terminal can unravel the mechanism behind computation, learning, and memory formation inside the brain. Recently, the discovery of $${Ca}^{2+}$$ -permeable channelrhodopsins (CapChRs) has opened...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Nripesh Dixit, Gur Pyari, Himanshu Bansal, Sukhdev Roy
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-04-01
Subjects:	Optogenetics Neurotransmitter Intracellular calcium concentration CapChR2 Synaptic efficacy
Online Access:	https://doi.org/10.1038/s41598-025-95355-6