Identification of SARS-CoV-2 Spike Palmitoylation Inhibitors That Results in Release of Attenuated Virus with Reduced Infectivity

The spike proteins of enveloped viruses are transmembrane glycoproteins that typically undergo post-translational attachment of palmitate on cysteine residues on the cytoplasmic facing tail of the protein. The role of spike protein palmitoylation in virus biogenesis and infectivity is being actively...

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Bibliographic Details

Published in:	Viruses
Main Authors:	Ahmed A. Ramadan, Karthick Mayilsamy, Andrew R. McGill, Anandita Ghosh, Marc A. Giulianotti, Haley M. Donow, Shyam S. Mohapatra, Subhra Mohapatra, Bala Chandran, Robert J. Deschenes, Arunava Roy
Format:	Article
Language:	English
Published:	MDPI AG 2022-03-01
Subjects:	SARS-CoV-2 palmitoylation S-acylation spike post-translational modifications DHHC9
Online Access:	https://www.mdpi.com/1999-4915/14/3/531