Hypoxic priming of mESCs accelerates vascular‐lineage differentiation through HIF1‐mediated inverse regulation of Oct4 and VEGF

Abstract Hypoxic microenvironment plays an important role in determining stem cell fates. However, it is controversial to which direction between self‐renewal and differentiation the hypoxia drives the stem cells. Here, we investigated whether a short exposure to hypoxia (termed ‘hypoxic‐priming’) e...

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Bibliographic Details

Published in:	EMBO Molecular Medicine
Main Authors:	Sae‐Won Lee, Han‐Kyul Jeong, Ji‐Young Lee, Jimin Yang, Eun Ju Lee, Su‐Yeon Kim, Seock‐Won Youn, Jaewon Lee, Woo Jean Kim, Kyu‐Won Kim, Jeong Mook Lim, Jong‐Wan Park, Young‐Bae Park, Hyo‐Soo Kim
Format:	Article
Language:	English
Published:	Springer Nature 2012-07-01
Subjects:	embryoid bodies endothelial cells mesoderm differentiation mouse embryonic stem cells niche
Online Access:	https://doi.org/10.1002/emmm.201101107