Evidence for Two Modes of Binding of the Negative Allosteric Modulator SB269,652 to the Dopamine D<sub>2</sub> Receptor

SB269,652 has been described as the first negative allosteric modulator (NAM) of the dopamine D<sub>2</sub> receptor (D<sub>2</sub>R), however, the binding mode and allosteric mechanism of action of this ligand remain incompletely understood. SB269,652 comprises an orthosteri...

詳細記述

書誌詳細
出版年:Biomedicines
主要な著者: Richard Ågren, Kristoffer Sahlholm
フォーマット: 論文
言語:英語
出版事項: MDPI AG 2021-12-01
主題:
オンライン・アクセス:https://www.mdpi.com/2227-9059/10/1/22