Intrachromosomal Amplification of Chromosome 21 (iAMP21) Impacts Event-Free Survival but Not Overall Survival Among Pediatric Patients with Acute Lymphoblastic Leukemia: A Single-Center Experience Using an Asparaginase-Intensified Spanish Regimen

Background/Objectives: Intrachromosomal amplification of chromosome 21 (iAMP21) represents a rare and heterogeneous distinct cytogenetic subgroup of B-cell precursor acute lymphoblastic leukemia (ALL) initially associated with a poor prognosis. Treatment intensification with additional doses of meth...

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Bibliographic Details

Published in:	Hemato
Main Authors:	María Hidalgo, Eduardo Ramos-Elbal, José Antonio Galián, Helios Martínez-Banaclocha, Mercedes Plaza, Victoria Martínez-Sánchez, Ana María Galera, Irene Jiménez, María Esther Llinares, Mar Bermúdez, Alfredo Minguela, José Luis Fuster
Format:	Article
Language:	English
Published:	MDPI AG 2025-06-01
Subjects:	children acute lymphoblastic leukemia intrachromosomal amplification of chromosome 21 iAMP21
Online Access:	https://www.mdpi.com/2673-6357/6/3/19