Mechanistic Study of Common Non-Nucleoside Reverse Transcriptase Inhibitor-Resistant Mutations with K103N and Y181C Substitutions

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are a mainstay of therapy for human immunodeficiency type 1 virus (HIV-1) infections. However, their effectiveness can be hampered by the emergence of resistant mutations. To aid in designing effective NNRTIs against the resistant mutants, it...

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書誌詳細

出版年:	Viruses
主要な著者:	Ming-Tain Lai, Vandna Munshi, Meiqing Lu, MeiZhen Feng, Renee Hrin-Solt, Philip M. McKenna, Daria J. Hazuda, Michael D. Miller
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2016-09-01
主題:	resistance mechanism K103N Y181C non-nucleoside reverse transcriptase inhibitor NNRTI-associated mutations
オンライン･アクセス:	http://www.mdpi.com/1999-4915/8/10/263