Long-Term Effects of Ivabradine on Cardiac Vagal Parasympathetic Function in Normal Rats

Background: The complex interactions that exist between the pacemaker current, If, and the parasympathetic nervous system could significantly influence the course of patients undergoing chronic therapy with the If blocker ivabradine. We thus aimed to assess the effects of chronic ivabradine therapy...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Alina Scridon, Vasile Bogdan Halaţiu, Alkora Ioana Balan, Dan Alexandru Cozac, Valeriu Moldovan, Claudia Bănescu, Marcel Perian, Răzvan Constantin Şerban
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-04-01
Subjects:	cardioinhibitory response HCN4 If current ivabradine vagal tone
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.596956/full