Inhibition of MAP4K4 signaling initiates metabolic reprogramming to protect hepatocytes from lipotoxic damage

The primary hepatic consequence of obesity is non-alcoholic fatty liver disease (NAFLD), affecting about 25% of the global adult population. Non-alcoholic steatohepatitis (NASH) is a severe form of NAFLD characterized by liver lipid accumulation, inflammation, and hepatocyte ballooning, with a diffe...

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Bibliographic Details

Published in:	Journal of Lipid Research
Main Authors:	Sumit Kumar Anand, Mara Caputo, Ying Xia, Emma Andersson, Emmelie Cansby, Sima Kumari, Marcus Henricsson, Rando Porosk, Katharina Susanne Keuenhof, Johanna Louise Höög, Syam Nair, Hanns-Ulrich Marschall, Matthias Blüher, Margit Mahlapuu
Format:	Article
Language:	English
Published:	Elsevier 2022-07-01
Subjects:	MAP4K4 non-alcoholic fatty liver disease non-alcoholic steatohepatitis liver steatosis hepatic lipid metabolism hepatic glycolysis
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227522000712