Cancer Cell Sensitivity to Redox-Cycling Quinones is Influenced by NAD(P)H: Quinone Oxidoreductase 1 Polymorphism

Background: Cancer cell sensitivity to drugs may be associated with disturbed antioxidant enzymes expression. We investigated mechanisms of resistance by using oxidative stress-resistant MCF-7 breast cancer cells (Resox cells). Since nicotinamide adenine dinucleotide phosphate (NAD(P)H): quinone oxi...

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Bibliographic Details

Published in:	Antioxidants
Main Authors:	Christophe Glorieux, Pedro Buc Calderon
Format:	Article
Language:	English
Published:	MDPI AG 2019-09-01
Subjects:	NQO1 NQO1*2 polymorphism quinone breast cancer menadione lapachone doxorubicin ascorbate oxidative stress
Online Access:	https://www.mdpi.com/2076-3921/8/9/369