CTLA4 DNA methylation is associated with CTLA-4 expression and predicts response to immunotherapy in head and neck squamous cell carcinoma

Abstract Background The majority of patients with recurrent or metastasized head and neck squamous cell carcinoma (HNSCC) do not benefit from immune checkpoint blockade (ICB) while several patients experience severe and persistent immune-mediated side effects. Therefore, predictive biomarkers are ur...

Full description

Bibliographic Details

Published in:	Clinical Epigenetics
Main Authors:	Friederike Hoffmann, Alina Franzen, Luka de Vos, Lennert Wuest, Zsófi Kulcsár, Simon Fietz, Alexander Philippe Maas, Sarah Hollick, Marie Yatou Diop, Jennis Gabrielpillai, Timo Vogt, Pia Kuster, Romina Zarbl, Joern Dietrich, Glen Kristiansen, Peter Brossart, Jennifer Landsberg, Sebastian Strieth, Dimo Dietrich
Format:	Article
Language:	English
Published:	BMC 2023-07-01
Subjects:	CTLA4 CTLA-4 Head and Neck Squamous Cell Carcinoma (HNSCC) DNA methylation Biomarker Immunotherapy
Online Access:	https://doi.org/10.1186/s13148-023-01525-6