Spinal cord vascular degeneration impairs duloxetine penetration

IntroductionChronic pain is a prevalent physically debilitating health-related morbidity. Frontline analgesics are inadequate, providing only partial pain relief in only a proportion of the patient cohort. Here, we explore whether alterations in spinal cord vascular perfusion are a factor in reducin...

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Bibliographic Details
Published in:Frontiers in Pain Research
Main Authors: M. E Da Vitoria Lobo, R Madden, S Liddell, M Hirashima, R. P Hulse
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Subjects:
pain
analgesia
duloxetine (DLX)
endothelial
spinal cord
VEGF—vascular endothelial growth factor
Online Access:https://www.frontiersin.org/articles/10.3389/fpain.2023.1190440/full

Internet

https://www.frontiersin.org/articles/10.3389/fpain.2023.1190440/full

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