Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma

Summary: Phosphatidylserine (PS) is exposed on the surface of apoptotic cells and is known to promote immunosuppressive signals in the tumor microenvironment (TME). Antibodies that block PS interaction with its receptors have been shown to repolarize the TME into a proinflammatory state. Radiation t...

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出版年:	Cell Reports
主要な著者:	Sadna Budhu, Rachel Giese, Aditi Gupta, Kelly Fitzgerald, Roberta Zappasodi, Sara Schad, Daniel Hirschhorn, Luis Felipe Campesato, Olivier De Henau, Mathieu Gigoux, Cailian Liu, Gregory Mazo, Liang Deng, Christopher A. Barker, Jedd D. Wolchok, Taha Merghoub
フォーマット:	論文
言語:	英語
出版事項:	Elsevier 2021-01-01
主題:	phosphatidylserine radiation therapy PD-1 melanoma immunotherapy immune modulation
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2211124720316090