Galectin-3 impairs calcium transients and β-cell function

Abstract In diabetes, macrophages and inflammation are increased in the islets, along with β-cell dysfunction. Here, we demonstrate that galectin-3 (Gal3), mainly produced and secreted by macrophages, is elevated in islets from both high-fat diet (HFD)-fed and diabetic db/db mice. Gal3 acutely reduc...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Qian Jiang, Qijin Zhao, Yibing Chen, Chunxiao Ma, Xiaohong Peng, Xi Wu, Xingfeng Liu, Ruoran Wang, Shaocong Hou, Lijuan Kong, Yanjun Wan, Shusen Wang, Zhuo-Xian Meng, Bing Cui, Liangyi Chen, Pingping Li
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-05-01
Online Access:	https://doi.org/10.1038/s41467-024-47959-1