DNA-PK as an Emerging Therapeutic Target in Cancer

The DNA-dependent protein kinase (DNA-PK) plays an instrumental role in the overall survival and proliferation of cells. As a member of the phosphatidylinositol 3-kinase-related kinase (PIKK) family, DNA-PK is best known as a mediator of the cellular response to DNA damage. In this context, DNA-PK h...

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Bibliographic Details
Published in:	Frontiers in Oncology
Main Authors:	Ismail S. Mohiuddin, Min H. Kang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-07-01
Subjects:	DNA-PKcs DNA-PK DNA repair chemotherapeutic target PRKDC
Online Access:	https://www.frontiersin.org/article/10.3389/fonc.2019.00635/full

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