PD-1+ CD4 T cell immune response is mediated by HIF-1α/NFATc1 pathway after P. yoelii infection

The morbidity and mortality of malaria are still high. Programmed cell death-1(PD-1) is an important co-inhibitory factor and CD8 T cells with PD-1 were reported to be exhausted cells. It remains unknown what the role of CD4 T cells expressing PD-1 is and what the upstream regulating molecules of PD...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Haixia Wei, Anqi Xie, Jiajie Li, Chao Fang, Lin Liu, Junmin Xing, Feihu Shi, Feng Mo, Dianhui Chen, Hongyan Xie, Quan Yang, Xingfei Pan, Xiaoping Tang, Jun Huang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-08-01
Subjects:	CD4 T cells PD-1 P. yoelii NFATc1 HIF-1α
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.942862/full