CRISPR/Cas-edited iPSCs and mesenchymal stem cells: a concise review of their potential in thalassemia therapy

Thalassemia, a prevalent single-gene inherited disorder, relies on hematopoietic stem cell or bone marrow transplantation as its definitive treatment. However, the scarcity of suitable donors and the severe complications from anemia and iron overload pose significant challenges. An immediate need ex...

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Bibliographic Details

Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Jiaojiao Shu, Xin Xie, Sixi Wang, Zuochen Du, Pei Huang, Yan Chen, Zhixu He
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	thalassemia gene therapy iPSC MSC complication
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2025.1595897/full