Pleiotropic association of LIPC variants with lipid and urinary 8-hydroxy deoxyguanosine levels in a Taiwanese population

Abstract Background Hepatic lipase (HL, encoded by LIPC) is a glycoprotein primarily synthesized and secreted by hepatocytes. Previous studies had demonstrated that HL is crucial for reverse cholesterol transport and affects the metabolism, composition, and level of several lipoproteins. In current...

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Bibliographic Details

Published in:	Lipids in Health and Disease
Main Authors:	Ming-Sheng Teng, Semon Wu, Lung-An Hsu, I-Shiang Tzeng, Hsin-Hua Chou, Cheng-Wen Su, Yu-Lin Ko
Format:	Article
Language:	English
Published:	BMC 2019-05-01
Subjects:	Hepatic lipase Single-nucleotide polymorphism Mediation analysis Suppression effect Triglyceride level High-density lipoprotein cholesterol level
Online Access:	http://link.springer.com/article/10.1186/s12944-019-1057-9