RoAM: computational reconstruction of ancient methylomes and identification of differentially methylated regions

Abstract We present a new and considerably improved version of RoAM (Reconstruction of Ancient Methylation), a flexible tool for reconstructing ancient methylomes and identifying differentially methylated regions (DMRs) between populations. Through a series of filtering and quality control steps, Ro...

Full description

Bibliographic Details

Published in:	Genome Biology
Main Authors:	Yoav Mathov, Naomi Rosen, Chen Leibson, Eran Meshorer, Benjamin Yakir, Liran Carmel
Format:	Article
Language:	English
Published:	BMC 2025-09-01
Subjects:	Ancient DNA methylation Human evolution Ancient DNA Neolithic transition Dietary shifts
Online Access:	https://doi.org/10.1186/s13059-025-03702-7