Synthesis and antitumor evaluation of amino acid conjugates of monocarbonyl curcumin in hepatocellular carcinoma cell

Abstract Curcumin possesses a variety of pharmacological properties, particularly anticancer activity. However, its clinical utility is limited by its poor water solubility and low bioavailability. To alleviate the problems, our previous research demonstrated that mono-carbonyl curcumin easters can...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Weiya Cao, Pan Yu, Yongchang Cao, Shuhui Feng, Nan Yin
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-03-01
Subjects:	Mono-carbonyl Curcumin Amino acid conjugates Anti-hepatoma activity AKT/FOXO1 pathway Molecular Docking Xenograft model
Online Access:	https://doi.org/10.1038/s41598-025-93451-1