Altered endoplasmic reticulum calcium loading in human PLN-R14del cardiomyopathy

The phospholamban (PLN) R14del genetic variant causes dilated cardiomyopathy. Previous studies suggest involvement of the ER stress response and impairment of ER-related signaling pathways such as autophagy. In this study, human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs) from...

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Bibliographic Details

Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Willem Borbein, Lukas Dahmlos, Umber Saleem, Marina Reinsch, Ingke Braren, Thomas Schulze, Birgit Klampe, Friederike Cuello, Justus Stenzig, Thomas Eschenhagen, Arne Hansen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Subjects:	phospholamban R14del human induced pluripotent stem cells engineered heart tissue endoplasmic reticulum CEPIAer
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2025.1627985/full