Probe substrates assay estimates the effect of polyphyllin H on the activity of cytochrome P450 enzymes in human liver microsomes

Abstract Cytochrome P450 enzymes (CYPs) play a crucial role in phase I metabolic reactions. The activity of CYPs would affect therapeutic efficacy and may even induce toxicity. Given the complex components of traditional Chinese medicine, it is important to understand the effect of active ingredient...

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Bibliographic Details

Published in:	Pharmacology Research & Perspectives
Main Authors:	Erhao Wang, Mengxi Wang, Ming Gao
Format:	Article
Language:	English
Published:	Wiley 2024-10-01
Subjects:	CYP450 drug–drug interaction IC50 Rhizoma paridis (Liliaceae) time‐dependent inhibition
Online Access:	https://doi.org/10.1002/prp2.70002