Acetylcysteine increases sensitivity of ceftazidime-avibactam–resistant enterobacterales with different enzymatic resistance to ceftazidime-avibactam in vitro and in vivo

Abstract Background Ceftazidime-avibactam (CZA) improves treatment outcomes for infections caused by carbapenem-resistant organisms, but has led to serious bacterial resistance. Acetylcysteine (NAC) is an approved medication that protects the respiratory tract through antioxidant and anti-inflammato...

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Bibliographic Details

Published in:	BMC Microbiology
Main Authors:	Zeyu Huang, Yijia Han, Xiaotuan Zhang, Yao Sun, Yuzhan Lin, Luozhu Feng, Tieli Zhou, Zhongyong Wang
Format:	Article
Language:	English
Published:	BMC 2023-11-01
Subjects:	Enterobacterales Ceftazidime-avibactam Antimicrobial resistance Acetylcysteine
Online Access:	https://doi.org/10.1186/s12866-023-03068-5