Targeted delivery of CEBPA-saRNA for the treatment of pancreatic ductal adenocarcinoma by transferrin receptor aptamer decorated tetrahedral framework nucleic acid

Abstract Pancreatic cancer, predominantly pancreatic ductal adenocarcinoma (PDAC), remains a highly lethal malignancy with limited therapeutic options and a dismal prognosis. By targeting the underlying molecular abnormalities responsible for PDAC development and progression, gene therapy offers a p...

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Bibliographic Details

Published in:	Journal of Nanobiotechnology
Main Authors:	Li Wang, Qunyan Yao, Xuerui Guo, Bingmei Wang, Jingyi Si, Xingye Wang, Shisong Jing, Ming Yan, Yan Shi, Guangqi Song, Xizhong Shen, Jiyu Guan, Yicheng Zhao, Changfeng Zhu
Format:	Article
Language:	English
Published:	BMC 2024-07-01
Subjects:	Tetrahedral framework nucleic acid Small activating RNA Pancreatic ductal adenocarcinoma CCAAT/enhancer-binding protein alpha Aptamer RNA delivery
Online Access:	https://doi.org/10.1186/s12951-024-02665-4